About us

We are a clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of novel or highly differentiated biologics to treat diseases with significant unmet medical needs, particularly cancers and autoimmune disorders. Our mission is to bring transformational medicines to patients through innovation.

We see vast commercial opportunities for immuno-oncology and autoimmune biologics therapies in China and rest of the world. We were founded to capture the opportunities presented by the confluence of two major developments: the emergence of an attractive and growing biologics market in China, and revolutionary scientific breakthroughs in cancer and autoimmune disease medicines. 

To achieve our mission and capitalize on these commercial opportunities, we have developed a business model built on two pillars. The first is a fast-to-market China approach, and the second a fast-to-PoC (proof of concept) global approach. Reflecting these two approaches, we have established a China Portfolio and a Global Portfolio of novel or highly differentiated clinical and preclinical assets in the most exciting therapeutic areas of immuno-oncology and immuno-inflammation. Through our internal research and development efforts, and in-licensing arrangements with global pharmaceutical and biotech companies, we have built an innovative pipeline of more than ten assets in clinical and preclinical stages of development. We are currently running three Phase 1 clinical trials in the US, and a further four trials, mostly Phase 2 or 3, in China. 

We believe we are uniquely positioned as a China-based global player, with a presence in Shanghai, Beijing and the US, to tap into these vast commercial opportunities. Since its founding in 2016, I-Mab has rapidly become one of the top innovative biotech companies in China, and we have successfully raised more than US$400 million in equity financing from our dedicated group of investors, including leading healthcare-focused funds.  Our research and development capabilities encompass discovery, translational medicine, chemistry, manufacturing and controls (CMC) for biologics, pre-clinical development and clinical development, as well as business development functions. These integrated capabilities are strengthened by our deep understanding of China’s biologics regulatory framework combined with our direct access to extensive preclinical and clinical trial resources in China. I-Mab is now at a critical juncture to transition from a clinical-stage biotech company into a fully integrated end-to-end global biopharmaceutical company in the next few years.

Significant Progress

Our Vision

I-Mab’s competitive pipeline and dynamic business strategy makes it perfectly positioned to capitalize on unique business conditions in China: a growing talent pool of professionals with both global and local R&D expertise; a critical mass of CRO services operating according to global standards; a rapidly improving regulatory and drug-innovation environment; and large capital resources. These factors, coupled with the huge market potential of China’s vast patient population and growing global reach, give us remarkable power and speed in developing innovative medicines.



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Organization & Management Team

A core strength of I-Mab is our management team, which brings together decades of collective experience in drug discovery and development, for both global and Chinese markets. The expertise of our management, who are among the top talent in their respective fields, covers all aspects of R&D from candidate discovery and chemistry, manufacturing and controls (CMC) to clinical development and regulatory approval.

Founder and Honorary Chairman Jingwu Zang, MD, PhD
I-Mab has built a globally competitive pipeline and a highly experienced team. We are passionate to develop transformational medicines to improve patients’ lives.

Jingwu Zang, MD, PhD

Founder and Chairman

Dr. Zang obtained a medical degree from Shanghai JiaoTong University School of Medicine and a doctoral degree in immunology from the University of Brussels. He was a postdoctoral fellow at Harvard Medical School and obtained his U.S. medical license from the Texas Medical Board through a clinical residency at Baylor College of Medicine in Houston, USA. Dr. Zang’s academic career started at the Dr. L. Willems Institute (now the Biomedical Research Institute) and the University of Limburg in Belgium. He became a professor at Baylor College of Medicine and later joined the Chinese Academy of Sciences as the founding director for the Institute of Health Sciences and co-director for Institute Pasteur Shanghai. Dr. Zang has published more than 160 scientific papers in international journals including Science, The Lancet, Nature Medicine, and Nature Immunology, and has also contributed to several books and book chapters. Since 2007, Dr. Zang has held leadership positions in pharma R&D at GlaxoSmithKline, Simcere Pharmaceuticals and BioScinKin. Dr. Zang brings to I-Mab Biopharma significant academic research achievements, and extensive experience with clinical studies, organizational management and innovative drug development in both global and China pharma settings.

Research and Development

Joan Huaqiong Shen

MD, PhD.

CEO

Research and Development is led by Joan Huaqiong Shen, MD, PhD, CEO of I-Mab Biopharma. Dr. Shen is a US board-certified physician and holds a PhD in life sciences from Indiana University School of Medicine, where she was appointed as an adjunct professor in the department of psychiatry. She also completed fellowships in endocrinology, psychopharmacology and clinical pharmacology. Her scientific contributions have led to multiple research grant awards and more than 30 publications.

Dr. Shen’s pharmaceutical career began at Eli Lilly & Company, after which she held executive positions at Wyeth, Pfizer, Jiangsu Hengrui Medicine and Johnson & Johnson. She was the clinical head at Pfizer China and the Chief Medical Officer at Jiangsu Hengrui Medicine, where she built the largest clinical team among Chinese domestic pharma companies and established successful clinical trials in China, the US and Australia. At J&J, Dr. Shen served as China Development Head and oversaw all clinical development programs in China. During that time, multiple innovative drugs were approved by China NMPA, such as Sirturo, Olysio, Imbruvica, Simponi, Stelara and etc. 

Dr. Shen served as co-chair of the R&D core team, R&D-based Pharmaceutical Association in China (RDPAC). She also sits on the China New Drug Research Evaluation Executive Committee, and is currently a guest professor at the Beijing University Clinical Research Institute.

Chemistry, Manufacturing and Controls (CMC)

Zheru Zhang

PhD.

President, Head of CMC & Manufacturing

The CMC group is headed by Zheru Zhang, PhD, President, Head of CMC and Manufacturing.  Dr.Zhang obtained his PhD in biochemistry from the University of Alberta, Canada, and has more than 20 years of experience in CMC development and quality management in the pharmaceutical industry in the US, Korea and China. Dr. Zhang has extensive experience working with various regulatory authorities, including NMPA, FDA, EMA, MFDS, PMDA and TGA, on the development of biological products. Before joining I-Mab, Dr. Zhang held technical and management positions at Bristol-Myers Squibb and Johnson & Johnson, and also served as Vice President of Celltrion and President of Tasgen. During his pharma tenure, Dr. Zhang led or participated in Investigational New Drug applications for twenty biologics, and six global Biologics License Applications, including for the first biosimilar monoclonal antibody product approved in Europe, Japan and the US. Under the leadership of Dr. Zhang, the CMC organization is structured to include the following: process development function is led by Dr. Junhua Qiao; analytical development function is led by Dr. Xiangping Zhu; project management teams for China and Global portfolios are led by Dr. Charlie Zhang, Dr. Junhua Qiao and Dr. Sheng Yin; quality assurance function is led by Mr. Jack Qin.

I-Mab U.S.

Neil K. Warma, MBA

General Manager

I-Mab Biopharma USA, Limited

Neil Warma has been a successful healthcare entrepreneur for more than 25 years, having founded, managed and advised numerous biotech and pharmaceutical companies. Previously, as President and CEO of Opexa Therapeutics (NASDAQ: OPXA), a publicly traded biopharmaceutical company, Mr. Warma led the rebuilding of the company’s cell therapy platform and oversaw its advance through clinical development in autoimmune and orphan diseases. Prior to Opexa, he was CEO of Viron Therapeutics, a private biotechnology company developing novel protein-based therapeutics for cardiovascular disease and transplantation.

Mr. Warma spent several years in key management roles at Novartis Pharmaceuticals at its corporate headquarters in Basel, Switzerland, including time as Head of Global Pharma Policy and Advocacy, as well as in Global Marketing. Mr. Warma also founded and later sold MedExact, a company dedicated to providing clinical and treatment information to physicians and pharmaceutical companies over the Internet. As President, he oversaw the expansion of the operations in the US, Canada and France and its sale to a large European public company.

Mr. Warma obtained an honors degree in neuroscience from the University of Toronto and an International MBA from the Schulich School of Business at York University in Toronto.

Mr. Warma is responsible for leading the global expansion of I-Mab, with a focus on expanding the US business and building up I-Mab’s translational medicine group in the US, as well as further R&D and operational functions.

Finance

Jielun Zhu

MBA,CFA

Chief Financial Officer

As the Chief Financial Officer, Jielun Zhu, MBA, CFA, is in charge of the overall financial strategy and management, capital investment, corporate finance and investor relations. He is a veteran and expert in the finance industry, with over 11 years of experience in investment banking. From December 2015 to July 2018, prior to joining I-Mab, he served as a managing director and Asia Head of Healthcare Investment Banking and Capital Markets in Hong Kong for Jefferies Group LLC, a global full-service investment bank with a strong focus in healthcare.

At Jefferies, Mr. Zhu advised many biotechnology and healthcare clients globally on IPOs and other financings, as well as mergers and acquisitions. From August 2008 to September 2015, he worked for the Deutsche Bank Group in its Hong Kong office, occupying a succession of positions culminating in Director in the Corporate Finance Division, which entailed working with leading clients in the healthcare and other sectors in Greater China. From July 2007 to July 2008, he was an investment banker in Hong Kong with UBS AG. Before investment banking, Mr. Zhu was a strategy consultant in Boston focused on serving clients in the US pharmaceutical and biotechnology industry.

Mr. Zhu earned his MBA from Harvard Business School with distinction in June 2007 and his Bachelor of Arts degree with honors in mathematics-economics from Wesleyan University. He is also a Chartered Financial Analyst (CFA) charterholder.

Global Business and Corporate Development

Weimin Tang

PhD.

Executive Vice President of Global Business

The Global Business Development team and the Corporate Development team work closely to support I-Mab’s vision of becoming a fully integrated innovative biopharmaceutical company.

The Global Business Development team is led by Weimin Tang, PhD, who is responsible for the company’s overall business development strategy. Dr. Tang has a strong track record of successful global pharmaceutical business development. During his 15-year tenure in pharma business development, he worked at Pfizer, Bristol-Myers Squibb, Sanofi, and Johnson & Johnson. He also was Acting CEO of Hengrui Therapeutics, a US branch of Hengrui Pharmaceuticals. With broad experience in global and China marketplaces, the Business Development team works closely with other units within I-Mab to identify external partnering opportunities and a competitive pipeline. I-Mab remains actively engaged in in-licensing and out-licensing activities.

Raven Lin

PhD.

Vice President of Corporate Development

Corporate Development is led by Raven Lin, PhD. His team provides long-term corporate development strategic direction, which covers global partnerships, alliance management, manufacturing capability and commercialization. The team is also focused on building an enterprise ecosystem that meets the company’s long-term business goals and financial strategies. Dr. Lin is an experienced business development executive with a strong track record in the pharmaceutical industry. He has a wealth of experience in licensing and mergers and acquisition, project management, and marketing and sales from positions he held at Mycenax and SynCore Bio. He has successfully completed several business development and partnership deals at I-Mab.

Company Operations

Lili Qian

PhD.

Vice President & Secretary of the Board of Directors

Company operations encompass Human Resources, Administrative, Facilities, Legal, Procurement, Government Affairs, Public relations, and Auditing. The team is led by Vice President Dr. Lili Qian, PhD, who has extensive experience in R&D operations, including managing startup companies, budgeting, project management, fundraising, and government affairs. She previously worked at Simcere Pharmaceuticals and BioSciKin. Dr. Qian also serves as Secretary of the Board of Directors.

Scientific Advisory Board

Patricia LoRusso, DO, MA, PhD

Current Academic Appointments:Professor of Medicine and Associate Director of Innovative Medicine and Director of Early Therapeutics Disease-Aligned Team at Yale Cancer Center.

A Member of the NCI Board of Scientific Council.

R&D Highlights:Dr. LoRusso heads the early clinical trials program at Yale Cancer Center and has been Principal Investigator of the National Cancer Institute Phase 1/early phase clinical trials program grant for more than 20 years, and is currently primary investigator or co-investigator on numerous clinical trials.

Eric K. Rowinsky, MD

Current Academic Appointment:Adjunct Professor of Medicine at New York University School of Medicine.

Industry Experience:Advisor to C-Bridge Capital, US Chief Medical Officer for Everest Medicines, Inc.

R&D Highlights:At ImClone Systems (now a wholly owned subsidiary of Eli Lilly), Dr. Rowinsky and his team developed and registered cetuximab (Erbitux) and ramucirumab in five indications and two other monoclonal antibodies.

Howard L. Weiner, MD

Current Academic Appointment:Robert L. Kroc Professor of Neurology at the Harvard Medical School; Director of the Partners Multiple Sclerosis Center; Co-Director of the Ann Romney Center for Neurologic Diseases at Brigham & Women's Hospital in Boston

R&D Highlights:Dr. Weiner pioneered immunotherapy in multiple sclerosis (MS) and has investigated immune mechanisms in nervous system diseases including MS, Alzheimer's disease, amyotrophic lateral sclerosis, stroke and brain tumors.

Yilong Wu, MD

Current Academic Appointment:Professor of Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences and Guangdong Lung Cancer Institute; lifetime Director and former Vice President of Guangdong General Hospital (GGH); and Member of Board of Directors of the International Association Study of Lung Cancer (IASLC).

Winner of Outstanding Science Achievement from IASLC (IASLC Paul A. Bunn, Jr. MD Scientific Award).

R&D Highlights:Prof. Wu is a pioneer of lung cancer research in China, gaining tremendous recognition from peers all over the world. He has committed himself to battling thoracic oncology at the front line.

Timothy A Yap, MD, PhD

Current Academic Appointment:Associate Professor of Department of Investigational Cancer Therapeutics (Phase 1 Program) and the Department of Thoracic/Head and Neck Medical Oncology at the University of Texas MD Anderson Cancer Center; Associate Director of Translational Research in the Institute for Personalized Cancer Therapy.

Industry Experience:Medical Director of the Institute for Applied Cancer Science.

R&D Highlights:Dr. Yap’s main research focuses on first-in-human and combinatorial development of molecularly targeted agents and immunotherapies, and their acceleration through clinical studies using novel predictive and pharmacodynamics biomarkers.

Roy S. Herbst, MD, PhD

Current Academic Appointments:Ensign Professor of Medicine (Medical Oncology), Professor of Pharmacology, and Chief of Medical Oncology at Yale Cancer Center and Smilow Cancer Hospital; and Associate Cancer Center Director for Translational Research at Yale Cancer Center.

R&D Highlights: Dr. Herbst is nationally recognized for his leadership and expertise in lung cancer treatment and research. He has led the Phase 1 development of several of the new generation of targeted agents for non-small cell lung cancer (NSCLC) and participated in the registration of pembrolizumab for the treatment of advanced NSCLC.

Investors

TigerMed and BioSciKin were early investors when Third Venture Biopharma was first founded in 2015. Series A financing of Third Venture was led by I-Bridge Capital in 2016. In 2017, Third Venture Biopharma merged with Tasgen to become I-Mab Biopharma and subsequently completed the Series B financing of US$120 million. The Series B round was led by C-Bridge Capital, with Tasly and Genexine participating. The Series C round of US$200 million was completed in June 2018 and was led by Hony Capital, along with Hillhouse Capital, HOPU Investments, CDH Investment, Ally Bridge Group, Singapore-based EDB, and existing investors C-Bridge Capital and Tasly Capital. The proceeds of the financing are being primarily used to advance the preclinical and clinical development of the company’s core products and major pipeline assets with best-in-class and first-in-class potential.

About Hangzhou Tigermed Consulting

Hangzhou Tigermed Consulting Co., Ltd (SHE:300347) is a leading Contract Research Organization (CRO) in China dedicated to providing professional full clinical-trial services. Since its inception in 2004, Tigermed has been committed to accelerating medical product development while maintaining cost efficiency and quality.

Headquartered in Hangzhou, Tigermed operates 33 subsidiaries, 63 offices across China and 12 overseas offices in Hong Kong China, Taiwan China, the US, Switzerland, Canada, Korea, Australia, Japan, Malaysia, Singapore, India and Romania, with over 3,600 full-time staff. Tigermed has serviced more than 600 local and global clients in the conduct of more than 1,060 clinical trials. Tigermed is recognized as “The Innovative Clinical CRO” in China, owning to our involvement in the development of more than 150 innovative drugs.

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Contact

US (Office)

Suite 710, 9801 Washingtonian Blvd, Gaithersburg, Maryland 20878, USA

Tel: +1 301-670-2800 ex 1990

Beijing (Office)

Rm 15A02,15A/F, Dacheng Plaza, 127 Xuanwumen West Street, Xicheng District, Beijing, China 100031

Tel: + 86-10-5617 7946

Shanghai (Headquarter)

Suite 802, West Tower, OmniVision, 88 Shangke Road, Pudong District, Shanghai, China, 201210

Tel: +86-21-6057 8000

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